Stretch and explore through work that matters.

We focus on driving the immune response to find rare, diverse, and potent antibodies from any species against even the most difficult disease targets. This includes clever immunization strategies using various immunogen formats including nucleic acids and membrane proteins, development of assays using mammalian cell lines and primary cells, development of media conditions and cell enrichment strategies, and design of complex functional assays.

We are thoughtfully assembling a world-class team of manufacturing and operations specialists, scientists, and engineers. Building from the ground up with the freedom to innovate, this team will design, build, qualify, and operate a new CMC laboratory and a 130K sq ft GMP facility in Canada. By seamlessly integrating cutting-edge discovery and translational research, our CMC team will empower the development of high-quality treatments for GMP manufacturing.

Many of our technologies are built and designed in-house to automate the selection and isolation of individual antibody-producing immune cells. We design microfluidic devices, each capable of physically isolating many thousands of single cells to allow customized antibody screening assays. We use robotics and machine vision to image each chamber of our devices and select for antibody-specific hits, followed by automated recovery of the antibody-producing cells for sequencing. Our goal is to continuously push the throughput, capacity, and robustness of our system in search of rare and potent antibodies.

Our Partnering team focuses on building and supporting partnerships that aim to bring better drugs for patients. This includes analyzing commercial landscapes, generating and managing new business opportunities, launching new partnerships and growth strategies, and working with executive, scientific, and communication teams to advance AbCellera’s mission.

Our Preclinical and Clinical Development teams work together to advance innovative new antibody development candidates through the critical testing needed to bring safe and efficacious antibody medicines to patients. Our preclinical development team is focussed on conducting research to assess the safety, efficacy, and pharmacokinetics of antibodies to identify promising antibody drug candidates for further investigation in clinical trials. Our Clinical Development team oversees all activities related to testing potential new medicines in human trials, including working closely with regulatory authorities to ensure compliance with regulatory standards and ethical guidelines throughout the clinical trial process.

We are focussed on streamlining production and enhancing the scalability of our antibody therapeutics for clinical trials. We spend our days optimizing the manufacturing process by meticulously designing and refining protocols to ensure the efficient and consistent production of high-quality antibodies. Throughout the process, we work collaboratively with scientists, engineers, and other experts to meet the stringent quality standards and regulatory requirements for manufacturing antibody therapeutics.

We focus on bringing advanced protein-based technologies for everything from antigen-driven immune responses to production and characterization of high quality antibodies for disease treatment. This includes high-throughput recombinant expression and purification of soluble and membrane proteins, biophysical characterization, binding and functional validation, and developability analysis. We also perform protein engineering to optimize sequences and to unlock advanced therapeutic formats from bispecifics to CAR-T cell therapies.

Our Quality team provides quality assurance and quality control support to our CMC Process Development and Manufacturing teams, ensuring industry best practices that meet or exceed cGMP standards. The Quality team will support the design, qualification, and ongoing operational activities of AbCellera’s CMC laboratories and our fully-integrated drug substance/drug product clinical manufacturing facility in Vancouver, Canada.

Our students have that spark. They want to work hard on things that matter each and every day. Over an eight month work term, students from a variety of academic disciplines will develop the skills, knowledge, and capacity needed to discover, develop, and manufacture antibody medicines. Our students are the future of the Canadian biotech industry. Together, we will push forward our mission to make life-changing medicines for people at home and around the world.