Development of PSMA x CD3 T-cell engagers using an integrated, functional approach
de Puyraimond V, et al. American Association for Cancer Research® (AACR) Annual Meeting, April 2024
This poster describes the generation of PSMA x CD3 T-cell engagers (TCEs) for the treatment of castration-resistant prostate cancer. A function-first approach was used to identify TCEs that show significantly lower cytokine release than clinical benchmarks while maintaining potent killing of PSMA-expressing cancer cell lines.
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