Target-dependent considerations for the design of bispecific T-cell engagers

Mai M, et al. American Association for Cancer Research^® (AACR) Annual Meeting, April 2024

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This poster describes the generation of T-cell engagers (TCEs) for three solid tumor targets, PSMA, B7-H4, and 5T4, with functional profiles that are differentiated from clinical benchmarks. Molecules were engineered using a set of rare CD3-binding antibodies that consistently show potent tumor-cell killing and low cytokine release across multiple targets, demonstrating their potential to expand the therapeutic window across solid tumor indications.

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